Left-arm quick Wahab Riaz has been dropped for the series decider, Pakistan captain Sarfraz Ahmed confirmed on Monday.
Wahab, who returned to the side after a year, failed to impress in the first Test where he returned wicketless after bowling 27 overs.
Fellow left-armer Hamza appears the most likely man to replace him, though Shadab, who has recovered from a groin injury, could be considered if Pakistan want another spin-bowling option.
In the batting department, Fakhar is in line to make his Test debut, and replace injured Imam-ul-Haq, who fractured his finger in the drawn opening Test.
Pakistan: Sarfraz Ahmed (Captain & WK), Azhar Ali, Fakhar Zaman, Imam-ul-Haq, Babar Azam, Asad Shafiq, Haris Sohail, Usman Salahuddin, Yasir Shah, Shadab Khan, Bilal Asif, Mohammad Abbas, Hasan Ali, Wahab Riaz, Faheem Ashraf, Mir Hamza, Mohammad Rizwan, Mohammad Hafeez.
Australia: Tim Paine (Captain & WK), Ashton Agar, Brendan Doggett, Aaron Finch, Travis Head, Jon Holland, Usman Khawaja, Marnus Labuschagne, Nathan Lyon, Mitch Marsh, Shaun Marsh, Michael Neser, Matthew Renshaw, Peter Siddle, Mitchell Starc.