The head of Anesthesia department at the Baba Raghav Das Medical College in Gorakhpur, Dr Satish Kumar, surrendered before the court in connection with the death of many children due to a shortage of oxygen supply.
Dr Satish surrendered on Monday and has been sent to a 14-day judicial custody.
The Allahabad High Court had earlier refused to put a stay on the arrest of Dr Satish in the case.
Since August, the death toll in BRD Medical College has gone up to 415.
In 2016, the death toll of infants and children was 364.
Earlier, over 70 children had died in the same hospital due to the lack of oxygen supply in a week and another 70 in four days, thereafter. The hospital and the government had received flak over the negligence.
On 23 August, an FIR was registered against nine persons, including the suspended principal of the BRD Medical College, Dr Rajiv Mishra and two officials from the oxygen supplying agency the Pushpa Sales Private Limited.
