Deputy Chief Minister O. Panneerselvam, Health Minister C.Vijayabaskar and others were also present at the venue.
The first vaccine shot was given to a doctor in Government Rajaji Hospital.
In Tamil Nadu, the immunization exercise will be performed at 166 centres — government and private hospitals.
Both the vaccines — Covishield, manufactured by Serum Institute of India and Covaxin developed and manufactured by Bharat Biotech — will be used in the state.
According to officials, the first consignment of 536,500 doses of Covishied has already reached the state.
A total of 100 persons will be vaccinated at each centre.
Till Friday, a total of 8,29,573 people have tested positive for coronavirus in the state. A total of 12,251 persons have lost their lives due to the virus.